If you choose to consume cannabis, here are some factors that may affect your experience:
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Cannabinoid and terpene profiles
Each cannabis cultivar (commonly called strains) has a different combination of cannabinoids and terpenes. This means each strain may have a different effect. It is also important to note that cannabis genetics of named strains vary from state to state and often from brand to brand since the naming of the strain is up to the producer. A strain from one producer may be genetically different from another, even if they have the same name. By learning more about cannabinoid and terpene profiles, a consumer can get a better understanding of how these factors may affect their experience and to help with buying and use decisions.
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Product form
Some product forms are more potent on their own or become stronger based on how they are processed in our bodies. For example, a pre-roll joint with only flower might be around 20% THC. If you were to consume an edible with the same amount of THC, it would feel more powerful due to the metabolite 11-Hydroxy-THC described above.
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Product potency
The potency or intensity of cannabinoids in a product and how they were extracted can affect the experience. Products with lower THC percentages or milligrams of THC will be less potent than concentrates, which are also affected by the method of extraction.
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Frequency of cannabis consumption
Someone who is new to cannabis will not have to consume the same amount as a frequent cannabis user to get a similar effect. Consuming cannabis regularly increases “cannabis tolerance”. This means your body is getting used to cannabis, and the effect will be weaker. This doesn’t mean, however, that you have less THC in your system. A driver whose blood tests at five or more nanograms of THC per millimeter is still considered legally impaired regardless of how they feel. For those whose tolerance is increasing, you can “reset” your tolerance to a lower level by taking a temporary break from use.
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Stomach contents
How much cannabis your body absorbs from edibles varies depending on what and when you have eaten that day and how your body metabolizes cannabis. The effects of an edible after a meal might be felt more gradually, while an infused beverage on an empty stomach may have a more immediate impact. Foods with high levels of terpenes (like mangoes and black pepper, for example) may also impact how your body absorbs cannabis and can potentially change the effects.
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Metabolism
Everyone has a different metabolism. Cannabis is typically metabolized and primarily absorbed in the lungs when smoked and the liver when eaten. There is a reason why some people think edibles feel stronger and more potent than smoking cannabis. When you eat or drink cannabis products, THC is broken down in the liver and transforms into the metabolite 11-Hydroxy-THC, which is several times more potent than THC when it is smoked.
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Space and setting
Having a safe place to consume cannabis can influence the experience. Consuming in a setting that is relaxing may provide a better experience than a location where you are anxious. When consuming in your home, avoid smoke exposure for family members and neighbors. And never smoke in bed.
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Schedule
Depending on the type of product you are using consider your commitments for the next few hours. Avoid cannabis use before driving or activities that may put you or others at risk for injury. Also consider the physical and/or mental capacity you will need.